Vascular Disease in Systemic Sclerosis

Vascular Disease in Systemic Sclerosis

1Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94305, USA 2Department of Rheumatology, University Hospital Zurich, Gloriastr. 25, 8091 Zürich, Switzerland 3Division of Rheumatology, Johns Hopkins University, 5501 Hopkins Bayview Circle, Room 1B.7, Baltimore, MD 21224, USA 4Division of Immunolo...

Gastric Antral Vascular Ectasia in Systemic Sclerosis

Gastric antral vascular ectasia is a not so well-understood, and more rare, gastrointestinal manifestation of Systemic Sclerosis which can lead to chronic anemia. A high suspicion and better understanding of this rare manifestation is needed for early detection and treatment. Therapeutic regiments include iron supplementation with acid suppressive therapy, while endoscopic intervention has been...

Vascular involvement in systemic sclerosis (scleroderma)

Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and pathogenesis of the systemic autoimmunity, fibrosis, and fibroproliferative vasculopathy are unknown and debated. In this review, the spectrum of vascular abnormalities and the options currently available to tr...

Mechanisms of vascular damage in systemic sclerosis.

Although being classified as autoimmune connective tissue disease, dominant components of the pathophysiology of systemic sclerosis (SSc) consists of mechanisms of vascular damage, which can occur early in the course of the disease. Amongst them are abnormal vasoreactivity, hypoxia, insufficient neoangiogenesis and direct damage of vascular and perivascular cells. They result in a decreased cap...

Peyronie's disease in systemic sclerosis.